Polyamine-containing natural products: structure, bioactivity, and biosynthesis

文献类型： 外文期刊

第一作者： Long, Qingshan

作者： Long, Qingshan;Tang, Ying;Liu, Qingshu;Zhou, Wen;Zhou, Haibo;Bian, Xiaoying;Chen, Wu

作者机构：

期刊名称：NATURAL PRODUCT REPORTS （ 影响因子：11.9； 五年影响因子：12.4 ）

ISSN： 0265-0568

年卷期： 2023 年

页码：

收录情况： SCI

摘要： Covering: 2005 to August, 2023Polyamine-containing natural products (NPs) have been isolated from a wide range of terrestrial and marine organisms and most of them exhibit remarkable and diverse activities, including antimicrobial, antiprotozoal, antiangiogenic, antitumor, antiviral, iron-chelating, anti-depressive, anti-inflammatory, insecticidal, antiobesity, and antioxidant properties. Their extraordinary activities and potential applications in human health and agriculture attract increasing numbers of studies on polyamine-containing NPs. In this review, we summarized the source, structure, classification, bioactivities and biosynthesis of polyamine-containing NPs, focusing on the biosynthetic mechanism of polyamine itself and representative polyamine alkaloids, polyamine-containing siderophores with catechol/hydroxamate/hydroxycarboxylate groups, nonribosomal peptide-(polyketide)-polyamine (NRP-(PK)-PA), and NRP-PK-long chain poly-fatty amine (lcPFAN) hybrid molecules. Polyamine-containing natural products have been isolated from a wide range of terrestrial and marine organisms. Most of them exhibit remarkable and diverse activities with potential applications in human health and agriculture.

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