Palladium-Catalyzed Enantioselective [4+2] Cycloaddition of 4-Vinylbenzodioxinones with Barbiturate-Derived Alkenes: Con-struction of Chiral Spirobarbiturate-Chromanes

文献类型： 外文期刊

第一作者： Tang, Yi

作者： Tang, Yi;Huang, Mingxia;Ding, Siyuan;Liu, Xinyao;Huyang, Xiaochun;Guo, Hongchao;Tang, Yi;Huang, Mingxia;Ding, Siyuan;Liu, Xinyao;Huyang, Xiaochun;Guo, Hongchao;Wang, Bo

作者机构：

关键词： Palladium catalysis; asymmetric catalysis; cycloaddition; cyclic carbonate; alkene

期刊名称：CHEMISTRY-A EUROPEAN JOURNAL （ 影响因子：4.3； 五年影响因子：4.1 ）

ISSN： 0947-6539

年卷期： 2024 年 30 卷 24 期

页码：

收录情况： SCI

摘要： In this paper, Pd-catalyzed [4+2] decarboxylative cycloaddition of 4-vinylbenzodioxinones with barbiturate-derived alkenes has been developed, leading to various spirobarbiturate-chromane derivatives in high yields with excellent diastereo- and enantioselectivities. The scale-up reaction and further derivation of the product were demonstrated. A plausible reaction mechanism was also proposed. A palladium-catalyzed [4+2] decarboxylative cycloaddition of 4-vinybenzodioxinones with barbiturate-derived alkenes has been developed, providing the corresponding spirobarbiturate-chromane derivatives in generally high yields with excellent diastereo- and enantioselectivities. image

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