Mild infection induced by low-dose LPS does not impair follicular development and is beneficial to pregnancy in mice

文献类型： 外文期刊

第一作者： Du, Yazhuo

作者： Du, Yazhuo;Zeng, Yutian;Li, Shuo;Wang, Zhicheng;Su, Changqi;Zhang, Shilin;Ren, Yan;Zhang, Ming;Song, Tianzeng;Zhang, Ming;Song, Tianzeng

作者机构：

关键词： lipopolysaccharide (LPS); follicle development; embryo implantation; pregnancy; mild infection

期刊名称：FRONTIERS IN VETERINARY SCIENCE （ 影响因子：3.2； 五年影响因子：3.5 ）

ISSN：

年卷期： 2023 年 9 卷

页码：

收录情况： SCI

摘要： The reproductive tract is susceptible to infection by a variety of bacteria, which can impair ovarian and uterine function. However, there is little known about whether mild infection can harm follicle development and embryo implantation. Here our results showed that the immune response to a mild infection simulated by low-dose LPS induced inflammatory factor IL-1b expression and decreased MMP2 expression involved in embryo implantation. LPS treatment also inhibited the ovulation process and reduced litter weight. Despite the immune response and the disturbed ovulation induced by treatment with low-dose LPS, the overall result was beneficial to mouse pregnancy. This research provides the necessary foundation for exploring the effects of mild bacterial infection on ovarian and uterine function in mammals.

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