文献类型： 外文期刊
第一作者： Zhang, Yapeng
作者： Zhang, Yapeng;Cai, Wentao;Li, Qian;Wang, Yahui;Wang, Zezhao;Zhang, Qi;Xu, Lingyang;Xu, Lei;Hu, Xin;Zhu, Bo;Gao, Xue;Chen, Yan;Gao, Huijiang;Li, Junya;Zhang, Lupei;Xu, Lei
作者机构：
关键词： rumen development; carcass traits; beef cattle; transcriptome; GWAS enrichment analysis
期刊名称：FRONTIERS IN GENETICS （ 影响因子：4.772； 五年影响因子：4.933 ）
ISSN：
年卷期： 2022 年 13 卷
页码：
收录情况： SCI
摘要： Rumen development is a crucial physiological challenge for ruminants. However, the molecular mechanism regulating rumen development has not been clearly elucidated. In this study, we investigated genes involved in rumen development in 13 rumen tissues from three developmental stages (birth, youth, and adult) using RNA sequencing. We identified that 6,048 genes were differentially expressed among three developmental stages. Using weighted correlation network analysis, we found that 12 modules were significantly associated with developmental stages. Functional annotation and protein-protein interaction (PPI) network analysis revealed that CCNB1, CCNB2, IGF1, IGF2, HMGCL, BDH1, ACAT1, HMGCS2, and CREBBP involved in rumen development. Integrated transcriptome with GWAS information of carcass weight (CW), stomach weight (SW), marbling score (MS), backfat thickness (BFT), ribeye area (REA), and lean meat weight (LMW), we found that upregulated DEGs (fold change 0 similar to 1) in birth-youth comparison were significantly enriched with GWAS signals of MS, downregulated DEGs (fold change >3) were significantly enriched with GWAS signals of SW, and fold change 0 similar to 1 up/downregulated DEGs in birth-adult comparison were significantly enriched with GWAS signals of CW, LMW, REA, and BFT. Furthermore, we found that GWAS signals for CW, LMW, and REA were enriched in turquoise module, and GWAS signals for CW was enriched in lightgreen module. Our study provides novel insights into the molecular mechanism underlying rumen development in cattle and highlights an integrative analysis for illustrating the genetic architecture of beef complex traits.
分类号：
- 相关文献
作者其他论文 更多>>
-
Development of an enhanced hybrid attention YOLOv8s small object detection method for phenotypic analysis of root nodules
作者：Zhao, Ya;Zhang, Wen;Zhang, Liangxiao;Tang, Xiaoqian;Wang, Du;Zhang, Qi;Li, Peiwu;Tang, Xiaoqian;Zhang, Qi;Li, Peiwu;Zhao, Ya;Li, Peiwu
关键词：Root nodules; YOLOv8s; Hybrid attention mechanism; Small object detection; Phenotypic characteristics
-
Smartphone-assisted electrochemiluminescence imaging test strips towards dual-signal visualized and sensitive monitoring of aflatoxin B1 in corn samples
作者：Chen, Miao-Miao;Jiang, Jun;Tang, Xiaoqian;Zhang, Qi;Li, Peiwu;Chen, Miao-Miao;Jiang, Jun;Tang, Xiaoqian;Zhang, Qi;Li, Peiwu;Tang, Xiaoqian;Zhang, Qi;Li, Peiwu;Tang, Xiaoqian;Zhang, Qi;Li, Peiwu;Chen, Miao-Miao;Zhang, Min-Ling;Song, Xiao;Zhang, Xiuhua;Chen, Miao-Miao;Song, Xiao
关键词：Electrochemiluminescence imaging; Test strips; Nanomaterials; Dual-signal outputs; Aflatoxin B1; Food safety
-
Knockdown of tyrosine hydroxylase gene affects larval survival, pupation and adult eclosion in Plagiodera versicolora
作者：Liu, Xiaolong;Wang, Xin;Zhang, Qi;Lu, Min;Ze, Longji;Zhang, Hainan
关键词：cuticle tanning; mortality;
Plagiodera versicolora ; RNA interference; tyrosine hydroxylase -
Sublethal effects of lambda-cyhalothrin on the biological characteristics, detoxification enzymes, and genes of the papaya mealybug, Paracoccus marginatus
作者：Li, Jian-Yu;Chen, Yan-Ting;Chen, Yan;Zhao, Jian-Wei;Shi, Meng-Zhu;Fu, Jian-Wei;Shi, Meng-Zhu
关键词：Paracoccus marginatus; Lambda-cyhalothrin; Two-sex life table; P450; GST; Transcriptome
-
Context-dependent response of crop pests to landscape composition
作者：Yang, Long;Pan, Yunfei;Wyckhuys, Kris A. G.;Li, Minlong;Wang, Kaitao;Liu, Bing;Liu, Yangtian;Jia, Shuangshuang;Li, Qian;Li, Yan;Lu, Yanhui;Wyckhuys, Kris A. G.;Desneux, Nicolas
关键词：Agroecology; context dependency; ecological based pest management; ecological intensification; host quality
-
D-glucose-derived S-doped porous carbon: Sustainable and effective CO2 adsorption
作者：Xu, Qianyu;Wang, Junting;Feng, Jiamin;Liu, Chen;Hu, Xin;Xiao, Qiang;Demir, Muslum;Simsek, Utku Bulut;Demir, Muslum;Kilic, Murat;Wang, Linlin
关键词：S-doped porous carbons; Biomass; CO2 adsorption; Sodium thiosulfate, D-glucose
-
Antimicrobial Lobophorins from Endophytic Strain Streptomyces sp. R6 Obtained from Azadirachta indica
作者：Chen, Xinyuan;Du, Ying;Ma, Yunlong;Liu, Peibin;Chen, Yan
关键词：antimicrobial activity; Lobophorins; Polyketides; plant disease;
Streptomyces sp. R6
