Differential metabolism-associated gene expression of duck pancreatic cells in response to two strains of duck hepatitis A virus type 1

文献类型： 外文期刊

第一作者： Chen, Zhen

作者： Chen, Zhen;Shi, Shao-hua;Huang, Yu;Liu, Rong-chang;Cheng, Long-fei;Fu, Guang-hua;Chen, Hong-mei;Wan, Chun-he;Fu, Qiu-ling;Chen, Zhen;Shi, Shao-hua;Huang, Yu;Liu, Rong-chang;Cheng, Long-fei;Fu, Guang-hua;Chen, Hong-mei;Wan, Chun-he;Fu, Qiu-ling;Chen, Zhen;Shi, Shao-hua;Huang, Yu;Liu, Rong-chang;Cheng, Long-fei;Fu, Guang-hua;Chen, Hong-mei;Wan, Chun-he;Fu, Qiu-ling;Huang, Cui-qin

作者机构：

期刊名称：ARCHIVES OF VIROLOGY （ 影响因子：2.574； 五年影响因子：2.466 ）

ISSN： 0304-8608

年卷期： 2021 年 166 卷 11 期

页码：

收录情况： SCI

摘要： Several outbreaks of duck hepatitis A virus type 1 (DHAV-1), which were characterized by yellow coloration and hemorrhage in pancreatic tissues, have occurred in China. The causative agent is called pancreatitis-associated DHAV-1. The mechanisms involved in pancreatitis-associated DHAV-1 infection are still unclear. Transcriptome analysis of duck pancreas infected with classical-type DHAV-1 and pancreatitis-associated DHAV-1 was carried out. Deep sequencing with Illumina-Solexa resulted in a total of 53.9 Gb of clean data from the cDNA library of the pancreas, and a total of 29,597 unigenes with an average length of 993.43 bp were generated by de novo sequence assembly. The expression levels of D-3-phosphoglycerate dehydrogenase, phosphoserine aminotransferase, and phosphoserine phosphatase, which are involved in glycine, serine, and threonine metabolism pathways, were significantly downregulated in ducks infected with pancreatitis-associated DHAV-1 compared with those infected with classical-type DHAV-1. These findings provide information regarding differences in expression levels of metabolism-associated genes between ducks infected with pancreatitis-associated DHAV-1 and those infected with classical-type DHAV-1, indicating that intensive metabolism disorders may contribute to the different phenotypes of DHAV-1-infection.

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