UFL1, a UFMylation E3 ligase, plays a crucial role in multiple cellular stress responses

文献类型： 外文期刊

第一作者： Jiang, Qiang

作者： Jiang, Qiang;Xiang, Minghui;Hua, Jiamin;Zhou, Tianci;Cai, Yafei;Jiang, Qiang;Huang, Jinming;Wang, Yongsheng;Chen, Fanghui;Lv, Xiaoyang

作者机构：

关键词： UFL1; Ufmylation modification; ER stress; genotoxic stress; oncogenic stress; inflammation

期刊名称：FRONTIERS IN ENDOCRINOLOGY （ 影响因子：5.2； 五年影响因子：5.9 ）

ISSN： 1664-2392

年卷期： 2023 年 14 卷

页码：

收录情况： SCI

摘要： The UFM1 conjugation system(UFMylation)is a novel type of ubiquitin-like system that plays an indispensable role in maintaining cell homeostasis under various cellular stress. Similar to ubiquitination, UFMylation consists of a three-step enzymatic reaction with E1-like enzymes ubiquitin-like modifier activating enzyme5 (UBA5), E2-like enzymes ubiquitin-fold modifier-conjugating enzyme 1(UFC1), and E3-like ligase UFM1-specific ligase 1 (UFL1). As the only identified E3 ligase, UFL1 is responsible for specific binding and modification of the substrates to mediate numerous hormone signaling pathways and endocrine regulation under different physiological or pathological stress, such as ER stress, genotoxic stress, oncogenic stress, and inflammation. Further elucidation of the UFL1 working mechanism in multiple cellular stress responses is essential for revealing the disease pathogenesis and providing novel potential therapeutic targets. In this short review, we summarize the recent advances in novel UFL1 functions and shed light on the potential challenges ahead, thus hopefully providing a better understanding of UFMylation-mediated cellular stress.

分类号：

  • 相关文献
作者其他论文 更多>>

微信小程序