Mechanism Analysis of Metabolic Fatty Liver on Largemouth Bass (Micropterus salmoides) Based on Integrated Lipidomics and Proteomics

文献类型： 外文期刊

第一作者： Xue, Moyong

作者： Xue, Moyong;Xue, Min;Jia, Ming;Li, Junguo;Gu, Xu;Xue, Moyong;Francis, Frederic;Xue, Moyong;Qin, Yuchang;Yao, Ting

作者机构：

关键词： metabolic liver disease; integrated analysis; proteomics; lipidomics; largemouth bass

期刊名称：METABOLITES （ 影响因子：5.581； 五年影响因子：5.531 ）

ISSN：

年卷期： 2022 年 12 卷 8 期

页码：

收录情况： SCI

摘要： Metabolic fatty liver disease caused by high-starch diet restricted the intensive and sustainable development of carnivorous fish such as largemouth bass. In this study, the combination liver proteomic and lipidomic approach was employed to investigate the key signaling pathways and identify the critical biomarkers of fatty liver in largemouth bass. Joint analysis of the correlated differential proteins and lipids revealed nine common metabolic pathways; it was determined that FABP1 were significantly up-regulated in terms of transporting more triglycerides into the liver, while ABCA1 and VDAC1 proteins were significantly down-regulated in terms of preventing the transport of lipids and cholesterol out of the liver, leading to triglyceride accumulation in hepatocyte, eventually resulting in metabolic fatty liver disease. The results indicate that FABP1, ABCA1 and VDAC1 could be potential biomarkers for treating metabolic fatty liver disease of largemouth bass.

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