Cladodionen, a Cytotoxic Hybrid Polyketide from the Marine-Derived Cladosporium sp OUCMDZ-1635
文献类型： 外文期刊
第一作者： Zhu, Guoliang
作者： Zhu, Guoliang;Kong, Fandong;Wang, Yi;Fu, Peng;Zhu, Weiming;Kong, Fandong;Zhu, Weiming
作者机构：
关键词： marine-derived fungus; Cladosporium sp; OUCMDZ-1635; polyketide; cladodionen; cladosacid; cytotoxicities
期刊名称：MARINE DRUGS （ 影响因子：5.118； 五年影响因子：5.951 ）
ISSN： 1660-3397
年卷期： 2018 年 16 卷 2 期
页码：
收录情况： SCI
摘要： A new hybrid polyketide, cladodionen (1), together with a new abscisic acid analogue, cladosacid (2), were isolated from the marine-derived fungus, Cladosporium sp. OUCMDZ-1635. Their structures, including the absolute configurations, were fully elucidated on the basis of spectroscopic analysis, ECD spectra, quantum chemical calculations, and chemical methods. Cladodionen (1) showed cytotoxic activities against MCF-7, HeLa, HCT-116, and HL-60 human cancer cell lines with IC50 values of 18.7, 19.1, 17.9, and 9.1 mu M.
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