Cladodionen, a Cytotoxic Hybrid Polyketide from the Marine-Derived Cladosporium sp OUCMDZ-1635

文献类型: 外文期刊

第一作者: Zhu, Guoliang

作者: Zhu, Guoliang;Kong, Fandong;Wang, Yi;Fu, Peng;Zhu, Weiming;Kong, Fandong;Zhu, Weiming

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关键词: marine-derived fungus; Cladosporium sp; OUCMDZ-1635; polyketide; cladodionen; cladosacid; cytotoxicities

期刊名称:MARINE DRUGS ( 影响因子:5.118; 五年影响因子:5.951 )

ISSN: 1660-3397

年卷期: 2018 年 16 卷 2 期

页码:

收录情况: SCI

摘要: A new hybrid polyketide, cladodionen (1), together with a new abscisic acid analogue, cladosacid (2), were isolated from the marine-derived fungus, Cladosporium sp. OUCMDZ-1635. Their structures, including the absolute configurations, were fully elucidated on the basis of spectroscopic analysis, ECD spectra, quantum chemical calculations, and chemical methods. Cladodionen (1) showed cytotoxic activities against MCF-7, HeLa, HCT-116, and HL-60 human cancer cell lines with IC50 values of 18.7, 19.1, 17.9, and 9.1 mu M.

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