The global distribution and spread of the mobilized colistin resistance gene mcr-1

文献类型： 外文期刊

第一作者： Wang, Ruobing

作者： Wang, Ruobing;Wang, Qi;Wang, Xiaojuan;Jin, Longyang;Wang, Hui;van Dorp, Lucy;Shaw, Liam P.;Balloux, Francois;Bradley, Phelim;Iqbal, Zamin;Zhang, Qing;Liu, Yuqing;Rieux, Adrien;Dorai-Schneiders, Thamarai;Weinert, Lucy Anne;Iqbal, Zamin;Didelot, Xavier

作者机构：

期刊名称：NATURE COMMUNICATIONS （ 影响因子：14.919； 五年影响因子：15.805 ）

ISSN： 2041-1723

年卷期： 2018 年 9 卷

页码：

收录情况： SCI

摘要： Colistin represents one of the few available drugs for treating infections caused by carbapenem-resistant Enterobacteriaceae. As such, the recent plasmid-mediated spread of the colistin resistance gene mcr-1 poses a significant public health threat, requiring global monitoring and surveillance. Here, we characterize the global distribution of mcr-1 using a data set of 457 mcr-1-positive sequenced isolates. We find mcr-1 in various plasmid types but identify an immediate background common to all mcr-1 sequences. Our analyses establish that all mcr-1 elements in circulation descend from the same initial mobilization of mcr-1 by an ISApl1 transposon in the mid 2000s (2002-2008; 95% highest posterior density), followed by a marked demographic expansion, which led to its current global distribution. Our results provide the first systematic phylogenetic analysis of the origin and spread of mcr-1, and emphasize the importance of understanding the movement of antibiotic resistance genes across multiple levels of genomic organization.

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