MicroRNA-221 may be involved in lipid metabolism in mammary epithelial cells

文献类型： 外文期刊

第一作者： Chu, Meiqiang

作者： Chu, Meiqiang;Zhao, Yong;Yu, Shuai;Hao, Yanan;Zhang, Pengfei;Feng, Yanni;Ma, Dongxue;Li, Lan;Shen, Wei;Min, Lingjiang;Zhang, Hongfu;Liu, Jing;Cheng, Ming;Cao, Hongfang;Li, Qiang

作者机构：

关键词： MiR-221; Lipid; Metabolism; Estradiol; Progesterone; Lactation

期刊名称：INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY （ 影响因子：5.085； 五年影响因子：4.407 ）

ISSN： 1357-2725

年卷期： 2018 年 97 卷

页码：

收录情况： SCI

摘要： Milk lipids, important for infant growth and development, are produced and secreted by mammary gland under the regulation of steroid hormones, growth factors, and microRNAs (miRNAs). miR-221 has been identified in milk and adipocytes and it plays important roles in regulating normal mammary epithelial hierarchy and breast cancer stem cells; however, its roles in lipid metabolism in mammary epithelial cells (MECs), the cells of lipid synthesis and secretion, are as yet unknown. Through overexpression or inhibition of miR-221 expression, we found that it regulated lipid metabolism in MECs and was expressed differentially at various stages during murine mammary gland development. Inhibition of miR-221 expression increased lipid content in MECs through elevation of the lipid synthesis enzyme FASN, while overexpression of miR-221 reduced MEC lipid content. Moreover, the steroid hormones estradiol and progesterone decreased miR-221 expression with a subsequent increase in lipid formation in MECs. The expression of miR-221 was lower during lactation, which suggests that it may be involved in milk production. Therefore, miR-221 might be a useful target for influencing milk lipid production.

分类号：

  • 相关文献
作者其他论文 更多>>

微信小程序