Dietary glutamine supplementation enhances expression of ZO-1 and occludin and promotes intestinal development in Min piglets

文献类型： 外文期刊

第一作者： Zhang, Jing

作者： Zhang, Jing;Wu, Guochao;Jin, Yongcheng;Fang, Hengtong;Zhao, Yun;Shen, Jinglin;Zhou, Changhai;Li, Chunjin;Chen, Lu;Zhou, Yongfeng;Wang, Xin;Yu, Hao;Shan, Anshan;Han, Yu;Liu, Di

作者机构：

关键词： Glutamine; jejunum; occludin; zonula occludens; Min piglets

期刊名称：ACTA AGRICULTURAE SCANDINAVICA SECTION A-ANIMAL SCIENCE （ 影响因子：0.684； ）

ISSN： 0906-4702

年卷期： 2017 年 67 卷 1-2 期

页码：

收录情况： SCI

摘要： Forty-eight Min piglets at 7 days of age were randomly divided into two groups which were fed with 0% and 0.8% glutamine, respectively. Supplementation with 0.8% l-glutamine, the average daily gain (ADG) were significantly increased, and the concentrations of glutamine, glutamate, arginine and citrulline in plasma were significantly improved (P<.05). The expression of jejunal mucosa glutathione peroxidase (GSH-Px) and total superoxide dismutase (T-SOD) were both significantly increased, and the concentration of malonaldehyde (MDA) was significantly reduced (P<.05). Furthermore, the villus height and the villus height to crypt depth ratio were significantly increased (P<.05). Glutamine supplementation significantly increased the expression levels of occludin mRNA and protein (P<.05), while the mRNA and protein expression levels of ZO-1 were not significantly affected. These results showed that dietary supplementation with glutamine contributed to improving intestinal development and whole-body growth in Min piglets.

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