Clustering Analysis of Antibiograms and Antibiogram Types of Streptococcus agalactiae Strains from Tilapia in China

文献类型： 外文期刊

第一作者： Liu, Chan

作者： Liu, Chan;Feng, Juan;Xie, Yundan;Wang, Jiangyong;Su, Youlu;Liu, Chan;Xie, Yundan;Zhang, Defeng;Li, Anxing

作者机构：

关键词： tilapia; Streptococcus agalactiae; antibiogram; type clustering

期刊名称：MICROBIAL DRUG RESISTANCE （ 影响因子：3.431； 五年影响因子：3.275 ）

ISSN： 1076-6294

年卷期： 2018 年 24 卷 9 期

页码：

收录情况： SCI

摘要： In view of the changing antibiotic-resistance profiles of Streptococcus agalactiae from tilapia in China, antimicrobial susceptibilities of 75 S. agalactiae strains were determined by the disc diffusion method, and cluster analyses of the antibiograms and antibiogram types were performed. All strains displayed multidrug resistance (MDR). The antimicrobial-resistance rates were highest (>90%) to aminoglycosides, sulfonamides, pipemidic acid, and norfloxacin, followed by penicillin, ampicillin, and ciprofloxacin (26.7-38.7%); those to furadantin, lincomycin, erythromycin, ofloxacin, tetracycline, and florfenicol were low (<10%), and no resistance to vancomycin, cefalexin, cefoxitin, amoxicillin, medemycin, doxitard, oxytetracycline, rifampin, chloramphenicol, or thiamphenicol was detected. Statistical analysis showed that the resistance rate to ciprofloxacin increased significantly in 2016 (p=0.009), whereas that to trimethoprim/sulfamethoxazole decreased (p=0.017). Cluster analyses identified that the strains had 23 antibiogram types (A-W) and clustered in five groups (Groups I-V). The strains with higher antimicrobial resistance mainly clustered in Groups I and II. Our results show that the antibiograms varied with time and by location and that antibiogram types are constantly updating and expanding. Effective measures must be taken to reduce the antimicrobial resistance and spread of MDR strains.

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