Potential protective effect of Trans-10-hydroxy-2-decenoic acid on the inflammation induced by Lipoteichoic acid

文献类型： 外文期刊

第一作者： Chen, Yi-Fan

作者： Chen, Yi-Fan;You, Meng-Meng;Liu, Yi-Chen;Shi, Yi-Zhen;Lu, Yuan-Yuan;Hu, Fu-Liang;Wang, Kai

作者机构：

关键词： Royal jelly; 10-HDA; Lipoteichoic acid; Inflammation mediators; Acute lung injury

期刊名称：JOURNAL OF FUNCTIONAL FOODS （ 影响因子：4.451； 五年影响因子：4.907 ）

ISSN： 1756-4646

年卷期： 2018 年 45 卷

页码：

收录情况： SCI

摘要： Royal jelly (RI) is known as a functional food for its diverse health-beneficial properties and complicated chemical compositions. Trans-10-hydroxy-2-decenoic acid (10-HDA) is the exclusive lipid component in RJ. In the present study, the in vitro anti-inflammatory effect of 10-HDA in LTA (Lipoteichoic acid from Staphylococcus aureus) induced RAW 264.7 macrophages are evaluated. The results showed that 10-HDA had potent, dose dependent inhibitory effects on the release of major inflammatory mediators and NO. Several key inflammatory genes, including IL-113, IL-6, MCP-1 and COX-2 have also been suppressed by 10-HDA. Furthermore, the effects of 10-HDA on LTA-induced pulmonary damage were also examined in mice. It was found that the administration of 10-I-IDA (100 mg/kg) can provide protective effects by attenuating lung histopathological changes and modulating the secretion of LTA-stimulated inflammatory cytokines in mice, such as IL-10, MCP-1 and TNF-alpha. Conclusively, the results reveal the potent anti-inflammatory properties of 10-HDA and provide biological information for the future application.

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