Simultaneous and interference-free determination of eleven non-steroidal anti-inflammatory drugs illegally added into Chinese patent drugs using chemometrics-assisted HPLC-DAD strategy
文献类型： 外文期刊
第一作者： Wang, Tong
作者： Wang, Tong;Wu, Hai-Long;Xie, Li-Xia;Long, Wan-Jun;Cheng, Li;Ding, Yu-Jie;Yu, Ru-Qin;Liu, Zhi
作者机构：
关键词： non-steroidal anti-inflammatory drugs; Chinese patent drugs; high performance liquid chromatography-diode array detection; second-order calibration; alternating trilinear decomposition
期刊名称：SCIENCE CHINA-CHEMISTRY （ 影响因子：9.445； 五年影响因子：5.238 ）
ISSN： 1674-7291
年卷期： 2018 年 61 卷 6 期
页码：
收录情况： SCI
摘要： In this work, a smart strategy that combines three-way high performance liquid chromatography-diode array detection (HPLCDAD) data with second-order calibration method based on alternating trilinear decomposition (ATLD) algorithm was proposed for simultaneous determination of eleven non-steroidal anti-inflammatory drugs (NSAIDs) illegally added into Chinese patent drugs and health products. All target analytes were rapidly eluted out within 14.5 min under a simple gradient elution. With the aid of the prominent "second-order advantage" of the ATLD algorithm, three HPLC problems, i.e. peak overlaps, unknown interferences and baseline drift, could be mathematically calibrated, and pure signals of target analytes could be extracted out from heavy-interference but information-rich HPLC-DAD data. The average spiked recoveries for all target analytes were in the range of 95.9%-106.4% with standard deviations lower than 7.5%. Validation parameters including sensitivity (SEN), selectivity (SEL), limit of detection (LOD), limit of quantitation (LOQ) and precisions of intra-day and inter-day were calculated to validate the accuracy of the proposed method, quantitative results were further confirmed by the classic HPLC method, which proved that chemometrics-assisted HPLC-DAD analytical strategy was highly efficient, accurate and green for drug-abuse monitoring of NSAIDs in Chinese patent drugs and health products.
分类号：
- 相关文献
作者其他论文 更多>>
-
Identification and functional analysis of the Dof transcription factor genes in sugar beet
作者：Sun, Yaqing;Zhang, Yongfeng;Jian, Caiyuan;Wang, Tong;Cao, Guoli;Li, Ningning;Li, Guolong;Zhang, Shaoying;Zhang, Yongfeng;Jian, Caiyuan
关键词：Beta vulgaris L.; BvDof; Gene expression patterns; Root tuber development
-
Alleviating Clostridium perfringens-Induced Intestinal Lesions in Chickens Using the Xylanase CbXyn10C and Its Binary Cocktail with a Protease
作者：Zhang, Wenjing;Hao, Zhenzhen;Yang, Daoxin;Ji, Wangli;Guo, Kairui;Sun, Xianhua;Wang, Shuai;Yang, Shuyan;Ma, Jianshuang;Luo, Huiying;Yao, Bin;Wang, Yuan;Huang, Huoqing;Su, Xiaoyun;Wang, Tong;Zhang, Meiling
关键词：necrotic enteritis; Clostridium perfringens; xylanase; protease; broiler chickens; gut microbiota modulation
-
Geographical origin traceability of Xiaobai apricot (Prunus armeniaca L.cv.) using stable isotope and multi-element analysis
作者：Hu, Yunsha;Liu, Huaying;Bai, Baowei;He, Weizhong;Shen, Qi;Chen, Chang;Tian, Jing;Mei, Xianxian;Li, Bin;Yu, Shuqi;Liu, Zhi;Liu, Zhi
关键词：Xiaobai apricot; Stable isotope; Mineral element; Rare earth element; Origin traceability
-
Screening and functional verification of vernalization related transcription factor BrcFES1 in pak choi (Brassica rapa ssp. chinensis Makino)
作者：Hou, Ruize;Li, Xuan;Bao, Yue;Mao, Guilin;Wang, Tong;Chen, Qiliang;Li, Dong;Wang, Longda;Hou, Leiping;Li, Meilan;Zhao, Yanting;Zhao, Yanting
关键词：Brassica rapa ssp. chinensis Makino; Vernalization; Transcription factor; BrcFES1; DAP-Seq
-
Identification and genetic analysis of new ephemeroviruses in wild boars in China
作者：Tu, Zhongzhong;Wang, Tong;Tu, Changchun;Wang, Tong;Tu, Changchun;Xu, Yu;Sun, Heting;Peng, Peng;Qin, Siyuan
关键词：Wild boar; Ephemerovirus (EVs); Tick; China; Genetic diversity
-
Study on the influence mechanism of raw potato flour on the stability of ketchup
作者：Fu, Boqing;Fang, Jiahui;Gu, Zhengbiao;Hong, Yan;Cheng, Li;Fu, Boqing;Wang, Xu;Gu, Zhengbiao;Hong, Yan;Cheng, Li
关键词：Non-starch polysaccharides; Tomato; Rheology; Viscoelasticity; Water competition; Stability
-
Genome-Wide Association Study and Genomic Prediction of Soybean Mosaic Virus Resistance
作者：He, Di;Wu, Xintong;Liu, Zhi;Yang, Qing;Shi, Xiaolei;Yan, Long;He, Di;Yan, Long;Song, Qijian;Shi, Ainong;Li, Dexiao
关键词：soybean mosaic virus (SMV); genome-wide association study (GWAS); genomic prediction (GP); quantitative trait locus (QTL); marker-assisted selection (MAS)
