Nematicidal amide alkaloids from the seeds of Clausena lansium

文献类型： 外文期刊

第一作者： Chena, Hui-Qin

作者： Chena, Hui-Qin;Mei, Wen-Li;Kong, Fan-Dong;Li, Fei-Xiang;Chen, Peng-Wei;Cai, Cai-Hong;Dai, Hao-Fu;Fan, Yu-Jiao;Huang, Mian-Jia

作者机构：

关键词： Clausena lansium; Seeds; Amide alkaloids; Nematicidal activity

期刊名称：FITOTERAPIA （ 影响因子：2.882； 五年影响因子：3.202 ）

ISSN： 0367-326X

年卷期： 2018 年 128 卷

页码：

收录情况： SCI

摘要： Five new amide alkaloids (1-3, 5-6) were isolated from the seeds of Clausena lansium together with one new natural product (4) and four known analogues (7-10). The structures of the new amide alkaloids were elucidated based on a comprehensive spectroscopic data analysis including 1D and 2D NMR as well as HRESIMS, and by comparison with the literature. The bioactivity results showed that compound 8 expressed potent nematicidal activity against Panagrellus redivevus, with IC50 value of 0.12 mM, while compounds 3 and 5 presented moderate nematicidal activity with IC50 values of 2.75 and 3.93 mM, respectively (abamectin as the positive control with IC50 value of 1.05 mM).

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