Quantitative analysis of chloramphenicol, thiamphenicol, florfenicol and florfenicol amine in eggs via liquid chromatography-electrospray ionization tandem mass spectrometry

文献类型： 外文期刊

第一作者： Xie, Xing

作者： Xie, Xing;Wang, Ran;Wang, Bo;Zhao, Xia;Xie, Kaizhou;Zhang, Yangyang;Wang, Ya'juan;Guo, Ya'wen;Liu, Chu'jun;Bu, Xiao'na;Shi, Huiqiang;Zhang, Genxi;Zhang, Tao;Dai, Guojun;Wang, Jinyu;Wang, Bo;Zhao, Xia;Xie, Kaizhou;Zhang, Yangyang;Wang, Ya'juan;Guo, Ya'wen;Liu, Chu'jun;Bu, Xiao'na;Shi, Huiqiang;Zhang, Genxi;Zhang, Tao;Dai, Guojun;Wang, Jinyu;Pang, Maoda

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关键词： Chloramphenicol; Thiamphenicol; Florfenicol; Florfenicol amine; LC-ESI/MS/MS; Eggs

期刊名称：FOOD CHEMISTRY （ 影响因子：7.514； 五年影响因子：7.516 ）

ISSN： 0308-8146

年卷期： 2018 年 269 卷

页码：

收录情况： SCI

摘要： A widely applicable method involving liquid chromatography-electrospray ionization tandem triple quadrupole mass spectrometry (LC-ESI/MS/MS) was developed for the simultaneous determination of chloramphenicol, thiamphenicol, florfenicol, and florfenicol amine in eggs. Samples were extracted with ethyl acetate-acetonitrile-ammonium hydroxide (49: 49: 2, v/v) and defatted with hexane saturated with acetonitrile. The analysis was carried out on a mass spectrometer via an electrospray interface operated in the positive and negative ionization modes using deuterated chloramphenicol-d5 as the internal standard. The limits of detection and limits of quantification were 0.04-0.5 mu g/kg and 0.1-1.5 mu g/kg in eggs, respectively. The average recoveries of the four analytes from egg samples were 90.84-108.23%, with relative standard deviations of less than 9.61%. The corresponding intra-day and inter-day variations were found to be less than 8.11% and 11.30%, respectively. Finally, the new approach was successfully applied to the quantitative determination of these analytes in 50 commercial eggs from local supermarkets.

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