Anti-inflammatory effects of newly synthesized a-galacto-oligosaccharides on dextran sulfate sodium-induced colitis in C57BL/6J mice

文献类型： 外文期刊

第一作者： Dai, Zhuqing

作者： Dai, Zhuqing;Feng, Simin;Liu, Anna;Wang, Hong;Yang, Chung S.;Dai, Zhuqing;Zeng, Xiaoxiong;Feng, Simin;Dai, Zhuqing

作者机构：

关键词： Colitis; Anti-inflammatory; alpha-GOSg; Cyclooxygenase-2

期刊名称：FOOD RESEARCH INTERNATIONAL （ 影响因子：6.475； 五年影响因子：6.508 ）

ISSN： 0963-9969

年卷期： 2018 年 109 卷

页码：

收录情况： SCI

摘要： alpha-Galacto-oligosaccharides have been reported to have beneficial health effects. The purpose of this study was to investigate the preventive effects of a newly synthesized a-galacto-oligosaccharide mixture (alpha-GOSg), as well as raffinose family oligosaccharides (RFOs), on dextran sulfate sodium (DSS)-induced colitis in mice. When administered in drinking water at 0.5% for 15 days, both alpha-GOSg and RFOs significantly decreased fecal hemoglobin content, partially prevented colon length shortening, reduced the severity of colon inflammation, and attenuated DSS-induced upregulation of cyclooxygenase-2. In addition, the activation of the inflammatory regulator nuclear factor-kappa B was slightly inhibited by alpha-GOSg. The results showed that the newly synthesized alpha-GOSg preparation has similar anti-inflammatory activities as RFOs in this colitis model. The anti-inflammatory activity of alpha-GOSg in humans remains to be investigated.

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