Genetic assessment of inbred chicken lines indicates genomic signatures of resistance to Marek's disease

文献类型： 外文期刊

第一作者： Xu, Lingyang

作者： Xu, Lingyang;He, Yanghua;Ding, Yi;Song, Jiuzhou;Xu, Lingyang;Liu, George E.;Xu, Lingyang;Zhang, Huanmin;Cheng, Hans H.;Taylor, Robert L., Jr.

作者机构：

关键词： Genetic structure; Genomic signature; Homozygosity; Marek's disease; Recombinant Congenic Strains (RCS)

期刊名称：JOURNAL OF ANIMAL SCIENCE AND BIOTECHNOLOGY （ 影响因子：5.032； 五年影响因子：5.922 ）

ISSN： 2049-1891

年卷期： 2018 年 9 卷

页码：

收录情况： SCI

摘要： Background: Marek's disease (MD) is a highly contagious pathogenic and oncogenic disease primarily affecting chickens. However, the mechanisms of genetic resistance for MD are complex and not fully understood. MD-resistant line 6(3) and MD-susceptible line 7(2) are two highly inbred progenitor lines of White Leghorn. Recombinant Congenic Strains (RCS) were developed from these two lines, which show varied susceptibility to MD. Results: We investigated genetic structure and genomic signatures across the genome, including the line 6(3) and line 7(2), six RCSs, and two reciprocally crossed flocks between the lines 6(3) and 7(2) (F1 6(3) x 7(2) and F1 7(2) x 6(3)) using Affymetrix (R) Axiom (R) HD 600 K genotyping array. We observed 18 chickens from RCS lines were specifically clustered into resistance sub-groups distributed around line 6(3). Additionally, homozygosity analysis was employed to explore potential genetic components related to MD resistance, while runs of homozygosity (ROH) are regions of the genome where the identical haplotypes are inherited from each parent We found several genes including SIK, SOX1, LIG4, SIK1 and TNFSF13B were contained in ROH region identified in resistant group (line 6(3) and RCS), and these genes have been reported that are contribute to immunology and survival. Based on F-st based population differential analysis, we also identified important genes related to cell death and anti-apoptosis, including AKT1, API5, CDH13, CFDP and USP15, which could be involved in divergent selection during inbreeding process. Conclusions: Our findings offer valuable insights for understanding the genetic mechanism of resistance to MD and the identified genes could be considered as candidate biomarkers in further evaluation.

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