Prenylated Diphenyl Ethers from the Marine Algal-Derived Endophytic Fungus Aspergillus tennesseensis

文献类型： 外文期刊

第一作者： Li, Zhao-Xia

作者： Li, Zhao-Xia;Li, Wei;Wang, Xiu-Fang;Ren, Guang-Wei;Yuan, Xiao-Long;Deng, Ning;Ji, Gui-Xia;Zhang, Peng

作者机构：

关键词： marine-derived fungi; Aspergillus tennesseensis; secondary metabolites; diphenyl ethers; antimicrobial activity; cytotoxicity

期刊名称：MOLECULES （ 影响因子：4.411； 五年影响因子：4.587 ）

ISSN： 1420-3049

年卷期： 2018 年 23 卷 9 期

页码：

收录情况： SCI

摘要： Considerable attention has been paid to marine derived endophytic fungi, owing to their capacity to produce novel secondary metabolites with potent bioactivities. In this study, two new compounds with a prenylated diphenyl ether structure-diorcinol L (1) and (R)-diorcinol B (2)-were isolated from the marine algal-derived endophytic fungus Aspergillus tennesseensis, along with seven known compounds: (S)-diorcinol B (3), 9-acetyldiorcinol B (4), diorcinol C (5), diorcinol D (6), diorcinol E (7), diorcinol J (8), and a dihydrobenzofuran derivative 9. Their structures were elucidated by extensive NMR spectroscopy studies. Compound 2 represents the first example of an R-configuration in the prenylated moiety. All these isolated compounds were examined for antimicrobial and cytotoxic activities. Compounds 1-9 exhibited antimicrobial activities against some human-and plant-pathogenic microbes with MIC values ranging from 2 to 64 mu g/mL. Moreover, compound 9 displayed considerable inhibitory activity against the THP-1 cell line in vitro, with an IC50 value of 7.0 mu g/mL.

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