Genome-wide detection of selective signatures in a Duroc pig population

文献类型： 外文期刊

第一作者： Diao Shu-qi

作者： Diao Shu-qi;Luo Yuan-yu;Deng Xi;He Ying-ting;Gao Ning;Zhang Hao;Li Jia-qi;Chen Zan-mou;Zhang Zhe;Luo Yuan-yu;Ma Yun-long

作者机构：

关键词： Duroc; selective signature; candidate genes; REHH

期刊名称：JOURNAL OF INTEGRATIVE AGRICULTURE （ 影响因子：2.848； 五年影响因子：2.979 ）

ISSN： 2095-3119

年卷期： 2018 年 17 卷 11 期

页码：

收录情况： SCI

摘要： The Duroc pig has high adaptability and feeding efficiency, making it one of the most popular pig breeds worldwide. Over long periods of natural and artificial selection, genetic footprints, i.e., selective signatures, were left in the genome. In this study, a Duroc pig population (n=715) was genotyped with the Porcine SNP60K Bead Chip and the GeneSeek Genomic Profiler (GGP) Porcine Chip. The relative extended haplotype homozygosity (REHH) method was used for selective signature detection in a subset of the population (n=368), selected to represent a balanced family structure. In total, 154 significant core regions were detected as selective signatures (P<0.01), some of which overlap with previously reported quantitative trait loci associated with several economically important traits, including average daily gain and backfat thickness. Genome annotation for these significant core regions revealed a variety of interesting candidate genes including GATA3, TAF3, ATP5C1, and FGF1. These genes were functionally related to anterior/posterior pattern specification, phosphatidylinositol 3-kinase signaling, embryonic skeletal system morphogenesis, and oxidation-reduction processes. This research provides knowledge for the study of selection mechanisms and breeding practices in Duroc and other pigs.

分类号：

  • 相关文献
作者其他论文 更多>>

微信小程序