Potential of genotype VII Newcastle disease viruses to cause differential infections in chickens and ducks

文献类型： 外文期刊

第一作者： Meng, Chunchun

作者： Meng, Chunchun;Rehman, Zaib Ur;Liu, Kaichun;Qiu, Xusheng;Tan, Lei;Sun, Yingjie;Liao, Ying;Song, Cuiping;Yu, Shengqing;Ding, Chan;Meng, Chunchun;Ding, Chan;Meng, Chunchun;Ding, Chan;Ding, Zhuang;Nair, Venugopal;Munir, Muhammad

作者机构：

关键词： ducks; Newcastle disease virus; pathogenicity; phylogenetic analysis; sequencing

期刊名称：TRANSBOUNDARY AND EMERGING DISEASES （ 影响因子：5.005； 五年影响因子：4.622 ）

ISSN： 1865-1674

年卷期： 2018 年 65 卷 6 期

页码：

收录情况： SCI

摘要： Newcastle disease (ND), caused by ND virus (NDV), is one of the most infectious and economically important diseases of the poultry industry worldwide. While infections are reported in a wide range of avian species, the pathogenicity of chicken-origin virulent NDV isolates in ducks remains elusive. In this study, two NDV strains were isolated and biologically and genetically characterized from an outbreak in chickens and apparently healthy ducks. Pathogenicity assessment indices, including the mean death time (MDT), intracerebral pathogenicity index (ICPI) and cleavage motifs in the fusion (F) protein, indicated that both isolates were velogenic in nature. While these isolates carried pathogenic characteristics, interestingly they showed differential pathogenicity in ducks. The chicken-origin isolate caused high (70%) mortality, whereas the duck-origin virus resulted in low (20%) mortality in 4-week-old ducks. Intriguingly, both isolates showed comparable disease pathologies in chickens. Full-genome sequence analysis showed that the virus genome contains 15 192 nucleotides and carried features that are characteristic of velogenic strains of NDV. A phylogenetic analysis revealed that both isolates clustered in class II and genotype VII. However, there were several mutations in the functionally important regions of the fusion (F) and haemagglutinin-neuraminidase (HN) proteins, which may be responsible for the differential pathogenicity of these viruses in ducks. In summary, these results suggest that NDV strains with the same genotype show differential pathogenicity in chickens and ducks. Furthermore, chicken-origin virulent NDVs are more pathogenic for ducks than duck-origin viruses. These findings propose a role for chickens in the evolution of viral pathogenicity and the potential genetic resistance of ducks to poultry viruses.

分类号：

  • 相关文献
作者其他论文 更多>>

微信小程序