Isolation and phylogenetic analysis of an emerging Senecavirus A in China, 2017

文献类型： 外文期刊

第一作者： Liu, Cun

作者： Liu, Cun;Li, Xiubo;Liang, Lin;Li, Jinxiang;Cui, Shangjin;Li, Jinxiang;Liu, Cun;Li, Xiubo;Liang, Lin;Cui, Shangjin

作者机构：

关键词： Pig; Emerging disease; Phylogenetic analysis; Senecavirus A; Vesicular disease

期刊名称：INFECTION GENETICS AND EVOLUTION （ 影响因子：3.342； 五年影响因子：3.188 ）

ISSN： 1567-1348

年卷期： 2019 年 68 卷

页码：

收录情况： SCI

摘要： Senecavirus A (SVA), which is associated with porcine vesicular disease and high mortality in neonatal piglets, is a small non-enveloped RNA virus and a member of Picornaviridae family. An emerging SVA strain, named SVA CH/FuJ/2017, was isolated from vesicular liquid and vesicular lesion tissue from piglets with vesicular disease in Fujian province, China. In our study, the complete genome sequence of SVA CH/FuJ/2017 strain has been determined. The viral genome was 7285 nt in length. The homology analysis indicated that the gene sequences of polyprotein and VP1 in SVA CH/FuJ/2017 shared highest nucleotide identities with American SVA isolates; and polvprotein showed the highest similarity with American SVA isolates. The phylogenetic analysis based on polyprotein and VP1 nucleotide sequences indicated that SVA CH/FuJ/2017 was closely related to American SVA isolates. The results revealed that the novel SVA strain was closely related to those SVA strains that were isolated in America. Hence, the retrospective study is important for tracing the probable origin of China SVA strains.

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