Roles of microRNAs in T cell immunity: Implications for strategy development against infectious diseases

文献类型： 外文期刊

第一作者： Giri, Bikash R.

作者： Giri, Bikash R.;Cheng, Guofeng;Mahato, Ram I.

作者机构：

关键词： extracellular vesicles; immunity; infectious diseases; microRNAs; modulation; T cells

期刊名称：MEDICINAL RESEARCH REVIEWS （ 影响因子：12.944； 五年影响因子：12.341 ）

ISSN： 0198-6325

年卷期： 2019 年 39 卷 2 期

页码：

收录情况： SCI

摘要： T cell immunity plays a vital role in pathogen infections. MicroRNA (miRNAs) are small, single-stranded noncoding RNAs that regulate T cell immunity by targeting key transcriptional factors, signaling proteins, and cytokines associated with T cell activation, differentiation, and function. The dysregulation of miRNA expression in T cells may lead to specific immune responses and can provide new therapeutic opportunities against various infectious diseases. Here, we summarize recent studies that focus on the roles of miRNAs in T cell immunity and highlight miRNA functions in prevalent infectious diseases. Additionally, we also provide insights into the functions of extracellular vesicle miRNAs and attempt to delineate the mechanism of miRNA sorting into extracellular vesicles and their immunomodulatory functions. Moreover, methodologies and strategies for miRNA delivery against infectious diseases are summarized. Finally, potential strategies for miRNA-based therapies are proposed.

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