Hydropericardium syndrome caused by fowl adenovirus serotype 4 in replacement pullets

文献类型： 外文期刊

第一作者： Chen, Zhen

作者： Chen, Zhen;Shi, Shaohua;Lin, Su;Chen, Cuiteng;Zhu, Chunhua;Huang, Yu;Chen, Zhen;Shi, Shaohua;Lin, Su;Chen, Cuiteng;Zhu, Chunhua;Huang, Yu;Chen, Zhen;Shi, Shaohua;Lin, Su;Chen, Cuiteng;Zhu, Chunhua;Huang, Yu;Qi, Baoming

作者机构：

关键词： fowl adenovirus serotype 4; hydropericardium syndrome; replacement pullet

期刊名称：JOURNAL OF VETERINARY MEDICAL SCIENCE （ 影响因子：1.267； 五年影响因子：1.348 ）

ISSN： 0916-7250

年卷期： 2019 年 81 卷 2 期

页码：

收录情况： SCI

摘要： Hydropericardium syndrome (HPS) is one of the important emerging diseases causing huge losses to the poultry industry. It affects mainly 3-to 6-week-old broiler chickens and rarely occurs in breeding and laying flocks. Recently, an HPS case was recorded with a sudden heavy mortality in a 100-day-old laying flock. A fowl adenovirus serotype 4 (FAdV-4), named as GDMZ strain, was isolated and identified using polymerase chain reaction coupled with electron microscopy. The animal experiment showed that a mortality of 100% was recorded with hydropericardium as a conspicuous lesion throughout the course of infection. Microscopically, vacuolar changes and intranuclear inclusion bodies were observed in the liver and vacuolar changes were observed in the heart. The complete genome sequence of GDMZ strain was determined to investigate the molecular properties of GDMZ strain. The comparative analysis revealed that the novel Chinese FAdV-4 isolate contained open reading frame (ORF) 19, ORF27, and ORF48 genomic deletions. The phylogenetic analysis revealed that FAdV-4 could be divided into two major clades, of which Chinese FAdV-4 were located at a distinct clade.

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