Anti-MRSA Sesquiterpenes from the Semi-Mangrove Plant Myoporum bontioides A. Gray

文献类型： 外文期刊

第一作者： Dong, Li-Mei

作者： Dong, Li-Mei;Ouyang, Jin-Kui;Tan, Jian-Wen;Huang, Li-Lan;Dai, Hang;Gu, Wen-Xiang;Xu, Qiao-Lin;Jia, Xu-Chao

作者机构：

关键词： Myoporum bontioides; methicillin-resistant Staphylococcus aureus (MRSA); sesquiterpene alkaloids

期刊名称：MARINE DRUGS （ 影响因子：5.118； 五年影响因子：5.951 ）

ISSN： 1660-3397

年卷期： 2018 年 16 卷 11 期

页码：

收录情况： SCI

摘要： The striking rise of methicillin-resistant Staphylococcus aureus (MRSA) infections has become a serious threat to public health worldwide. In an effort to search for new anti-MRSA agents from natural products, a bioassay-guided phytochemical study was conducted on the semi-mangrove plant Myoporum bontioides A. Gray, which led to the isolation of two new sesquiterpene alkaloids (1 and 2) and six known furanosesquiterpenes (3-8). Their structures were elucidated on the basis of extensive analysis of their 1D, 2D NMR and mass spectroscopic data. These two new alkaloids (1 and 2) displayed potent anti-MRSA activity with MIC value of 6.25 g/mL. This is the first report of sesquiterpene alkaloids from the plants of Myoporum genus and their anti-MRSA activity.

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