Rapid evolution of a retro-transposable hotspot of ovine genome underlies the alteration of BMP2 expression and development of fat tails

文献类型： 外文期刊

第一作者： Pan, Zhangyuan

作者： Pan, Zhangyuan;Liu, Qiuyue;Zhou, Zhengkui;Di, Ran;An, Xuejiao;Wang, Xiangyu;Hu, Wenping;Guo, Xiaofei;Chu, Mingxing;Li, Shengdi;Wang, Zhen;Miao, Benpeng;Ding, Guohui;Li, Yixue;Pan, Zhangyuan;Lv, Shenjin;Li, Fukuan;Li, Shengdi;Miao, Benpeng;Ding, Guohui;Li, Yixue

作者机构：

关键词： Retro-transposable hotspot; BMP2; Fat tail; Sheep; Evolution

期刊名称：BMC GENOMICS （ 影响因子：3.969； 五年影响因子：4.478 ）

ISSN： 1471-2164

年卷期： 2019 年 20 卷

页码：

收录情况： SCI

摘要： BackgroundSheep have developed the ability to store fat in their tails, which is a unique way of reserving energy to survive a harsh environment. However, the mechanism underlying this adaptive trait remains largely unsolved.ResultsIn the present study, we provide evidence for the genetic determinants of fat tails, based on whole genome sequences of 89 individual sheep. A genome-wide scan of selective sweep identified several candidate loci including a region at chromosome 13, a haplotype of which underwent rapid evolution and spread through fat-tailed populations in China and the Middle East. Sequence analysis revealed an inter-genic origin of this locus, which later became a hotspot of ruminant-specific retro-transposon named BovB. Additionally, the candidate locus was validated based on a fat- and thin-tailed cross population. The expression of an upstream gene BMP2 was differentially regulated between fat-tailed and thin-tailed individuals in tail adipose and several other tissue types.ConclusionsOur findings suggest the fixation of fat tails in domestic sheep is caused by a selective sweep near a retro-transposable hotspot at chromosome 13, the diversity of which specifically affects the expression of BMP2. The present study has shed light onto the understanding of fat metabolism.

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