Ducks induce rapid and robust antibody responses than chickens at early time after intravenous infection with H9N2 avian influenza virus

文献类型： 外文期刊

第一作者： Yang, Jianmei

作者： Yang, Jianmei;Cui, Hongrui;Teng, Qiaoyang;Li, Xuesong;Wang, Binbin;Yan, Dawei;Chen, Hongjun;Liu, Qinfang;Li, Zejun;Yang, Jianmei;Cui, Hongrui;Teng, Qiaoyang;Li, Xuesong;Wang, Binbin;Yan, Dawei;Chen, Hongjun;Liu, Qinfang;Li, Zejun;Yang, Jianmei;Ma, Wenjun

作者机构：

关键词： Humoral immune response; Chickens; Ducks; H9N2 AIVs; Different routes

期刊名称：VIROLOGY JOURNAL （ 影响因子：4.099； 五年影响因子：3.719 ）

ISSN： 1743-422X

年卷期： 2019 年 16 卷

页码：

收录情况： SCI

摘要： BackgroundCompared with chickens, ducks are normally resistant to avian influenza virus without clinical signs while they habor almost all subtypes of influenza A viruses. To date, however the mechanism for duck anti-influenza has not been completely understood. The H9N2 avian influenza virus (AIV) is the most prevalent subtype of influenza A virus that infects chickens and ducks in China. However, H9N2 AIV replication and the host immune response in these domestic birds has not been systematically investigated.MethodsIn the present study, we compared the kinetics and magnitudes of antibody responses in chickens and ducks after infection with H9N2 AIV by the intranasal route or intravenous route. Furthermore, we determined the viral replication and distribution in chickens and ducks after infection with H9N2 AIV by the intravenous route.ResultsOur results revealed that the antibody response was rapid and robust in ducks than in chickens at early time (2-3dpi) after intravenous infection with H9N2 AIVs, while delayed and lower antibody detected in ducks than in chickens after intranasal infection with H9N2 AIVs. The virus was detected in multiple organs tissues in chickens but not in ducks infected by the intravenous route.ConclusionsOur results provide the evidence that humoral immune response could play a critical role in duck resistance for influenza, which expands our knowledge on duck anti-influenza characteristics.

分类号：

  • 相关文献
作者其他论文 更多>>

微信小程序