Citrus Flavanones Enhance beta-Carotene Uptake in Vitro Experiment Using Caco-2 Cell: Structure-Activity Relationship and Molecular Mechanisms

文献类型： 外文期刊

第一作者： Zhang, Zhongyuan

作者： Zhang, Zhongyuan;Nie, Meimei;Liu, Chunquan;Jiang, Ning;Liu, Chunju;Li, Dajing;Zhang, Zhongyuan;Li, Dajing;Nie, Meimei

作者机构：

关键词： citrus flavanone; beta-carotene; cellular uptake; structure-activity relationship; mechanism

期刊名称：JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY （ 影响因子：5.279； 五年影响因子：5.269 ）

ISSN： 0021-8561

年卷期： 2019 年 67 卷 15 期

页码：

收录情况： SCI

摘要： Flavonoids can interfere with the absorption of carotenoids. In this study, the inherent mechanisms of 12 citrus flavanones for beta-carotene (Bc) cellular uptake and the structure-activity relationship were investigated. The results showed that multiple hydroxyl groups had the lowest promoting effect. O-Glycosylation at C7 of the A ring led to the greatest promoting effect on Bc absorption. O-Glycosylation at C7 exhibited a strong affinity with the cell membrane and subsequently fluidized the cell membrane. Aglycon molecules significantly induced transient increases of paracellular permeability by decreasing tight junction proteins (ZO-1, claudin-1) expression. In addition, citrus flavanones might enhance scavenger receptor class B type I (SR-BI) expression via their actions as agonists of peroxisome proliferator-activated receptor-gamma (PPAR gamma). Catechol structure in the B-ring attenuated the activate action of SR-BI expression. The structure-dependent membrane permeability and activation of specific membrane proteins are mechanistically associated with the promoting effect on Bc cellular uptake by citrus flavanones.

分类号：

  • 相关文献
作者其他论文 更多>>

微信小程序