文献类型： 外文期刊
第一作者： Li, Wei
作者： Li, Wei;Wang, Hao;Dong, Wen-Hua;Cai, Cai-Hong;Gai, Cui-Juan;Yang, Li;Mei, Wen-Li;Dai, Hao-Fu;Li, Wei;Wang, Hao;Dong, Wen-Hua;Cai, Cai-Hong;Gai, Cui-Juan;Yang, Li;Mei, Wen-Li;Dai, Hao-Fu;Xia, Lu-Lu
作者机构：
关键词： Aquilaria crassna; Agarwood; 2-(2-Phenylethyl)chromone; Acetylcholinesterase inhibition activity; Cytotoxicity
期刊名称：PHYTOCHEMISTRY LETTERS （ 影响因子：1.679； 五年影响因子：1.861 ）
ISSN： 1874-3900
年卷期： 2019 年 31 卷
页码：
收录情况： SCI
摘要： One new 2-(2-phenylethyl)chromone (1), three new naturally occurring 2-(2-phenylethenyl)chromones (3-5), together with a known 2-(2-phenylethyl)chromone (2) were isolated from the EtOH extract of agarwood originating from Aquilaria crassna in Cambodia. Their structures were unambiguously elucidated by detailed spectroscopic (NMR, UV, IR, MS) analyses. All the compounds were tested for acetylcholinesterase (AChE) inhibitory activity and cytotoxicity against tumor cell lines (K562, BEL-7402, SGC-7901 and Hela). Compound 1 displayed weak AChE inhibitory activity (inhibitory ratio: 35.0 +/- 2.19%) and cytotoxicity against K562 tumor cell line (IC50) : 40.81 +/- 0.64 mu M). Along with, compound 3 showed cytotoxicity against BEL-7402 tumor cell line (IC50 : 44.18 +/- 0.34 mu M).
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