文献类型： 外文期刊
第一作者： Yan, Ming-Hao
作者： Yan, Ming-Hao;Hao, Jun-Hong;Zhang, Xue-Gang;Shen, Chao-Chao;Zhang, Da-Jun;Zhang, Ke-Shan;Zheng, Hai-Xue;Liu, Xiang-Tao
作者机构：
关键词： TPL2; Regulation; Innate immune; Research progress
期刊名称：IMMUNOBIOLOGY （ 影响因子：3.144； 五年影响因子：3.18 ）
ISSN： 0171-2985
年卷期： 2019 年 224 卷 3 期
页码：
收录情况： SCI
摘要： Tumor progression locus 2 (TPL2) is a serine/threonine kinase that belongs to the MAP3K family. The activated TPL2 regulates the innate immune-relevant signaling pathways, such as ERK, JNK, and NF-kappa B, and the differ. entiation of immune cells, for example, CD4+ T and NK cells. Therefore, TPL2 plays a critical role in regulating the innate immune response. The present review summarizes the recent advancements in the TPL2-regulated innate immune response.
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