Sec62 Suppresses Foot-and-Mouth Disease Virus Proliferation by Promotion of IRE1 alpha-RIG-I Antiviral Signaling

文献类型： 外文期刊

第一作者： Han, Shichong

作者： Han, Shichong;Mao, Lejiao;Sun, Shiqi;Zhang, Zhihui;Mo, Yaxia;Liu, Haiyun;Zhi, Xiaoying;Guo, Huichen;Liao, Ying;Lin, Shunmei;Seo, Ho Seong

作者机构：

期刊名称：JOURNAL OF IMMUNOLOGY （ 影响因子：5.422； 五年影响因子：6.029 ）

ISSN： 0022-1767

年卷期： 2019 年 203 卷 2 期

页码：

收录情况： SCI

摘要： Foot-and-mouth disease virus (FMDV) is highly infectious and causes a major plague in animal farming. Unfolded protein response is one of the major cellular responses to pathogenic infections, which performs a crucial role in cell survival, apoptosis, and antiviral innate immune response. In this study, we showed that FMDV infection activated two unfolded protein response branches (PERK-eIF2 alpha and ATF6 signaling) in both baby hamster kidney cells (BHK-21) and porcine kidney (PK-15) cells, whereas it suppressed the IRE1 alpha-XBP1 signaling by decreasing IRE1 alpha level. Further study revealed IRE1 alpha signaling as an important antiviral innate immune mechanism against FMDV. Sec62, the transport protein, was greatly decreased at the late stages of FMDV infection. By overexpression and knockdown study, we also found that the expression of Sec62 was positively involved in the levels of IRE1 alpha and RIG-I and subsequent activation of downstream antiviral signaling pathways in FMDV-infected PK-15 cells. Taken together, our study demonstrates that Sec62 is an important antiviral factor that upregulates IRE1 alpha-RIG-I-dependent antiviral innate immune responses, and FMDV evades antiviral host defense mechanism by downregulating Sec62-IRE1 alpha/RIG-I.

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