Three new 2-(2-phenylethyl)chromone derivatives from agarwood of Aquilaria crassna Pierre ex Lecomte (Thymelaeaceae) in Laos
文献类型: 外文期刊
第一作者: Zhao, Yang-Mei
作者: Zhao, Yang-Mei;Yang, Li;Dong, Wen-Hua;Li, Wei;Chen, Hui-Qin;Wang, Hao;Cai, Cai-Hong;Gai, Cui-Juan;Mei, Wen-Li;Dai, Hao-Fu;Yang, Li;Dong, Wen-Hua;Li, Wei;Chen, Hui-Qin;Wang, Hao;Cai, Cai-Hong;Gai, Cui-Juan;Mei, Wen-Li;Dai, Hao-Fu;Zhao, Yang-Mei
作者机构:
关键词: Agarwood; Aquilaria crassna Pierre ex Lecomte (Thymelaeaceae); 2-(2-Phenylethyl)chromone; Tyrosinase inhibition
期刊名称:PHYTOCHEMISTRY LETTERS ( 影响因子:1.679; 五年影响因子:1.861 )
ISSN: 1874-3900
年卷期: 2019 年 32 卷
页码:
收录情况: SCI
摘要: In our ongoing effort to study the metabolites from agarwood of Aquilaria crassna Pierre ex Lecomte (Thymelaeaceae) produced in Laos, three new 2-(2-phenylethyl)chromone derivatives (1 - 3) were isolated. Their structures were elucidated by comprehensive spectroscopic analyses, predominantly by 1D and 2D NMR spectroscopic methods, and by comparison with the reported data. Compound 2 exhibited tyrosinase inhibitory activity with IC50, value of 172.6 +/- 1.7 mu M (kojic acid as the positive control, 46.1 +/- 1.3 mu M) and its inhibition mode was clarified by molecular modelling study. None of the isolates showed significant cytotoxicity towards tested cancer cell lines.
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