Comparison of apoptosis between bovine subcutaneous and intramuscular adipocytes by resveratrol via SIRT1

文献类型： 外文期刊

第一作者： Zhang, Xianglun

作者： Zhang, Xianglun;Wan, Fachun;You, Wei;Tan, Xiuwen;Liu, Guifen;Jin, Qing;Wei, Chen;Liu, Xiaomu;Zhao, Hongbo;Liu, Yifan;Zhang, Chen;Zhang, Xianglun;Wan, Fachun;You, Wei;Tan, Xiuwen;Liu, Guifen;Jin, Qing;Wei, Chen;Liu, Xiaomu;Zhao, Hongbo;Liu, Yifan;Zhang, Chen;Wan, Fachun;Zhang, Chen

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关键词： SIRT1; resveratrol; bovine intramuscular adipocytes; bovine subcutaneous adipocytes; apoptosis

期刊名称：ANIMAL BIOTECHNOLOGY （ 影响因子：2.282； 五年影响因子：1.702 ）

ISSN： 1049-5398

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收录情况： SCI

摘要： A better understanding of the differential mechanisms regulating the deposition and release of fat between intramuscular and external adipose tissues is very important to the quality of beef. Resveratrol is a natural activator of sirtuin type 1 (SIRT1), a NAD-dependent deacetylase involved in regulating the cell cycle, energy homeostasis and apoptosis in adipose tissue. To compare the molecular mechanisms underlying differential apoptosis in bovine intramuscular and subcutaneous adipocytes, we evaluated the effect of resveratrol on differentiated adipocytes. We found that resveratrol-induced apoptosis in bovine adipocytes by regulating SIRT1 activity. In addition, we report that bovine intramuscular and subcutaneous adipocytes exhibited differential responses to resveratrol. In particular, gene and protein expression of Bcl-2 was higher, whereas that of SIRT1, AMPK alpha, FOXO1, Bax and caspase-3 were lower in bovine subcutaneous adipocytes than in intramuscular adipocytes. After resveratrol-treatment, the extent of up- or down-regulation was higher in subcutaneous adipocytes than in intramuscular adipocytes. These data indicate that bovine subcutaneous adipocytes are more sensitive to apoptosis than intramuscular adipocytes following treatment with resveratrol by regulating SIRT1 activity.

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