文献类型： 外文期刊
第一作者： Nawaz, Mohsin
作者： Nawaz, Mohsin;Malik, Muhammad Irfan;Hameed, Muddassar;Zhou, Jinlin
作者机构：
关键词： Exosomes; Excretory-Secretory products; Proteomics; Transcriptomics; Cytokines
期刊名称：ACTA TROPICA （ 影响因子：3.112； 五年影响因子：3.002 ）
ISSN： 0001-706X
年卷期： 2019 年 196 卷
页码：
收录情况： SCI
摘要： Parasites use excretory-secretory pathways to communicate with the host. Characterization of exosomes within the excretory-secretory products reveal by which parasites manipulate their hosts. Parasite derived exosomes provide a mechanistic framework for protein and miRNAs transfer. Transcriptomics and proteomics of parasite exosomes identified a large number of miRNAs and proteins being utilized by parasites in their survival, reproduction and development. Characterization of proteins and miRNAs in parasite secreted exosomes provide important information on host-parasite communication and forms the basis for future studies. In this review, we summarize recent advances in isolation and molecular characterization (protein and miRNAs) of parasite derived exosomes.
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