A diverse English keyword search reveals the value of scriptaid treatment for porcine embryo development following somatic cell nuclear transfer

文献类型： 外文期刊

第一作者： Li, Wei

作者： Li, Wei;Zheng, Hui;Yang, Yali;Xu, Hong;Guo, Zhenhua

作者机构：

关键词： blastocyst; cloning; embryo; HDACi; in vitro maturation; meta-analysis; SCNT; scriptaid

期刊名称：REPRODUCTION FERTILITY AND DEVELOPMENT （ 影响因子：1.973； 五年影响因子：2.124 ）

ISSN： 1031-3613

年卷期： 2022 年 34 卷 11 期

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收录情况： SCI

摘要： Context. Incomplete epigenetic reprogramming of histone deacetylation (HDAC) is one of the main reasons for the low efficiency of somatic cell nuclear transfer (SCNT). Scriptaid is a synthetic HDAC inhibitor (HDACi) that may improve the efficiency of porcine SCNT. Aims. This study aimed to determine whether scriptaid increases the number of blastocyst cells or the cleavage rate. Methods. We conducted a meta-analysis of the pertinent literature published over the past decade. Key results. A total of 73 relevant papers were retrieved using a diverse English keyword search, and I I articles were used for the meta-analysis. Scriptaid was positively correlated with blastocyst rate but had no effect on cleavage rate or blastocyst cell number. A subgroup analysis of blastocyst cell number showed that the staining method was the source of the heterogeneity. Conclusions. In SCNT embryos, scriptaid treatment after activation can promote embryonic development, but there may be adverse effects on early development. Implications. HDACi research should focus on SCNT birth efficiency.

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