Design, Synthesis, Antibacterial Activity, and Mechanism of Novel Mesoionic Compounds Based on Natural Pyrazole Isolated from an Endophytic Fungus Colletotrichum gloeosporioides

文献类型： 外文期刊

第一作者： Cui, Honghao

作者： Cui, Honghao;Wu, Zengxue;Zhang, Luoman;Ma, Qingqing;Cai, Di;Zhang, Jian;Hu, Deyu;Cui, Honghao

作者机构：

关键词： endophytic fungus; pyrimidine pyrazoles; mesoionic; anti-Xoo activity; defensive enzyme; proteomic

期刊名称：JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY （ 影响因子：6.1； 五年影响因子：6.3 ）

ISSN： 0021-8561

年卷期： 2023 年 71 卷 26 期

页码：

收录情况： SCI

摘要： Xanthomonas oryzae pv. oryzicola (Xoo) is a type of bacteria thatcauses bacterialleaf blight disease in rice plants. This disease is substantiallyharmful, and the current prevention and control measures are facingchallenges. This study has investigated the effectiveness of the controlactivity that the endophytic fungus NS7 fermented from Dendrobium candidum possessed against Xoo. Twenty-eight novel mesoionic compounds were designed and synthesizedbased on the natural compound D. These compounds displayedmoderate to excellent anti-Xoo activity invitro. Notably, compound 24 exhibited prominentanti-Xoo activity in vitro withan EC50 value of 40.3 mg/L, which was better than thatof the positive control thiodiazole copper (TC)(71.2 mg/L) and thelead compound D (108.1 mg/L). In vivo pot experiments on Xoo showed that compound 24 exhibited protective and curative activities of 39.4 and30.4%, respectively, which were better than those of TC (35.7 and28.8%, respectively). Further, a preliminary mechanism study indicatedthat compound 24 could enhance the activity of defenseenzymes to improve the ability for anti-Xoo. Meanwhile,compound 24 could also regulate the carbon fixation inphotosynthetic organisms, which might be related to the enhanced immunefunction of rice. This study offers a new strategy for discoveringantibacterial agents based on natural products.

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