Six unprecedented 2-(2-phenethyl)chromone dimers from agarwood of Aquilaria filaria

文献类型： 外文期刊

第一作者： Wei, Yuan

作者： Wei, Yuan;Dong, Wen-Hua;Li, Wei;Zeng, Jun;Chen, Hui-Qin;Huang, Sheng-Zhuo;Yang, Li;Wang, Ya-Li;Dai, Hao-Fu;Wang, Hao;Wei, Yuan;Guo, Zhi-Yong

作者机构：

关键词： Aquilaria filaria; Agarwood; 2-(2-Phenylethyl)chromone dimer; Tyrosinase inhibitory activity; Anti-inflammatory activity

期刊名称：FITOTERAPIA （ 影响因子：3.4； 五年影响因子：3.3 ）

ISSN： 0367-326X

年卷期： 2024 年 175 卷

页码：

收录情况： SCI

摘要： Six new dimeric 2-(2-phenylethyl)chromones ( 1 - 6 ) were successfully isolated from the ethanol extract of agarwood of Aquilaria filaria from Philippines under HPLC-MS guidance. Compounds 1 - 6 are all dimers formed by linking 5,6,7,8-tetrahydro-2-(2-phenylethyl)chromone and flindersia 2-(2-phenylethyl)chromone via a single ether bond, and the linkage site (C5-O-C8 '' ) of compound 2 is extremely rare. A variety of spectroscopic methods were used to ascertain their structures, including extensive 1D and 2D NMR spectroscopic analysis, HRESIMS, and comparison with literature. The in vitro tyrosinase inhibitory and anti-inflammatory activities of each isolate were assessed. Among these compounds, compound 2 had a tyrosinase inhibition effect with an IC 50 value of 27.71 +/- 2.60 mu M, and compound 4 exhibited moderate inhibition of nitric oxide production in lipopolysaccharide-stimulated RAW264.7 cells with an IC 50 value of 35.40 +/- 1.04 mu M.

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