Redox-sensitive self-assembling polymer micelles based on oleanolic modified hydroxyethyl starch: Synthesis, characterisation, and oleanolic release

文献类型： 外文期刊

第一作者： Kang, Lingtao

作者： Kang, Lingtao;Chang, Xia;Su, Zhipeng;Fu, Fuhua;Shan, Yang;Guo, Jiajing;Li, Gaoyang;Kang, Lingtao;Han, Xiaolei;Chang, Xia;Su, Zhipeng;Fu, Fuhua;Shan, Yang;Guo, Jiajing;Li, Gaoyang;Kang, Lingtao;Chang, Xia;Su, Zhipeng;Fu, Fuhua;Shan, Yang;Guo, Jiajing;Li, Gaoyang

作者机构：

关键词： Polymer micelles; Hydroxyethyl starch; Oleanolic; Redox-sensitive

期刊名称：INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES （ 影响因子：8.2； 五年影响因子：7.8 ）

ISSN： 0141-8130

年卷期： 2024 年 266 卷

页码：

收录情况： SCI

摘要： Our study aimed at developing polymer micelles that possess redox sensitivity and excellent controlled release properties. 3,3 ' -dithiodipropionic acid (DTDPA, Abbreviation in synthetic polymers: SS) was introduced as ROS (Reactive oxygen species)response bond and connecting arm to couple hydroxyethyl starch (HES) with oleanolic acid (OA), resulting in the synthesis of four distinct grafting ratios of HES-SS-OA. FTIR (Fourier Transform infrared spectroscopy) and 1 H NMR ( 1 H Nuclear magnetic resonance spectra) were used to verify the triumphant combination of HES-SS-OA. Polymer micelles were found to encapsulate OA in an amorphous form, as indicated by the results of XRD (X-ray diffraction) and DSC (Differential scanning calorimetry). When the OA grafting rate on HES increased from 7.72 % to 11.75 %, the particle size decreased from 297.79 nm to 201.39 nm as the polymer micelles became compact due to enhanced hydrophobicity. In addition, the zeta potential changed from -16.42 mv to -25.78 mv, the PDI (polydispersity index) decreased from 0.3649 to 0.2435, and the critical micelle concentration (CMC) decreased from 0.0955 mg/mL to 0.0123 mg/mL. Results of erythrocyte hemolysis, cytotoxicity and cellular uptake illustrated that HES-SS-OA had excellent biocompatibility and minimal cytotoxicity for AML -12 cells. Disulfide bond breakage of HES-SS-OA in the presence of H 2 O 2 and GSH confirmed the redox sensitivity of the HES-SS-OA micelles and their excellent controlled release properties for OA. These findings suggest that HES-SS-OA can be potentially used in the future as a healthcare drug and medicine for the prevention or adjuvant treatment of inflammation.

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