Synthesis of churros-like V2Se9 nanostructures for ultrasensitive electrochemical detection of oxalic acid in urine with portable point-of-care diagnostic devices

文献类型： 外文期刊

第一作者： Shi, Peizheng

作者： Shi, Peizheng;Xu, Lixin;Shi, Peizheng;Ye, Chen;Sun, Zhuang;Sun, Kaiqiang;Zhao, Ningbin;Ye, Chen;Cai, Tao;Nishimura, Kazuhito;Jiang, Nan;Ye, Chen;Cai, Tao;Nishimura, Kazuhito;Jiang, Nan;Lin, Cheng-Te;Pourfakhr, Mahan;Chen, Jun;Tsai, Hsu-Sheng;Wu, Lidong;Wu, Wenqi;Wu, Wenqi;Yu, Jiancheng;Yu, Jiancheng;Yu, Jiancheng;Fu, Li

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关键词： Electrochemical biosensors; Oxalic acid; Point-of-care testing; Biomonitoring

期刊名称：BIOSENSORS & BIOELECTRONICS （ 影响因子：10.5； 五年影响因子：10.1 ）

ISSN： 0956-5663

年卷期： 2025 年 285 卷

页码：

收录情况： SCI

摘要： The binding of oxalic acid (OA) with metal ions, particularly calcium ions, is a key factor in kidney stone formation, as it produces insoluble calcium oxalate, which crystallizes and accumulates in the kidneys. Consequently, OA in urine is commonly considered a significant biomarker for clinical diagnosis and early screening of kidney stones. This study reports churros-like V2Se9 nanostructures synthesized using a solvothermal method (high pressure and temperature) for sensitive and selective electrochemical detection of OA in urine. The electrodes made of churros-like V2Se9 hybridized with reduced graphene oxide (rGO) for OA recognition, demonstrated a linear range from 20 nM to 4 mM, with an extremely low detection limit of 9.7 nM. To enable fast, user friendly, and accurate point-of-care testing (POCT) for OA in urine samples, we designed and developed a portable workstation integrated with smartphone for data visualization. This is the first study to utilize the V2Se9 system for highly sensitive biosensor applications, highlighting its potential to advance screening techniques for key indicators of kidney stones by incorporating novel transition metal chalcogenide nanomaterials in POCT devices.

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