Crosstalk between Dysfunctional Mitochondria and Proinflammatory Responses during Viral Infections

文献类型： 外文期刊

第一作者： Sun, Zitao

作者： Sun, Zitao;Wang, Yanjin;Li, Su;Qiu, Hua-Ji;Sun, Zitao;Jin, Xin

作者机构：

关键词： mitochondrial dysfunction; mitochondrial damage; proinflammatory responses; innate immunity

期刊名称：INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES （ 影响因子：4.9； 五年影响因子：5.7 ）

ISSN： 1661-6596

年卷期： 2024 年 25 卷 17 期

页码：

收录情况： SCI

摘要： Mitochondria play pivotal roles in sustaining various biological functions including energy metabolism, cellular signaling transduction, and innate immune responses. Viruses exploit cellular metabolic synthesis to facilitate viral replication, potentially disrupting mitochondrial functions and subsequently eliciting a cascade of proinflammatory responses in host cells. Additionally, the disruption of mitochondrial membranes is involved in immune regulation. During viral infections, mitochondria orchestrate innate immune responses through the generation of reactive oxygen species (ROS) and the release of mitochondrial DNA, which serves as an effective defense mechanism against virus invasion. The targeting of mitochondrial damage may represent a novel approach to antiviral intervention. This review summarizes the regulatory mechanism underlying proinflammatory response induced by mitochondrial damage during viral infections, providing new insights for antiviral strategies.

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