Quercetin inhibits largemouth bass rhabdovirus infection by enhancing the immune response in Micropterus salmoides

文献类型： 外文期刊

第一作者： Xue, Mingyang

作者： Xue, Mingyang;Xu, Chen;Huang, Zhenyu;Jiang, Nan;Li, Yiqun;Meng, Yan;Fan, Yuding;Zhou, Yong;Jiang, Yangyang

作者机构：

关键词： Antivirals; largemouth bass rhabdovirus (LMBRaV); Quercetin; Immunomodulator; Micropterus salmoides

期刊名称：ISRAELI JOURNAL OF AQUACULTURE-BAMIDGEH （ 影响因子：0.4； 五年影响因子：0.5 ）

ISSN： 0792-156X

年卷期： 2025 年 77 卷 1 期

页码：

收录情况： SCI

摘要： The Largemouth bass Rhabdovirus (LMBRaV) is a highly virulent pathogen that results in substantial mortality rates and economic losses within the largemouth bass (Micropterus salmoides) aquaculture industry. The utilization of medicinal plant extracts has emerged as a promising strategy for combating aquatic animal diseases. In this study, we aimed to evaluate the anti-LMBRaV properties effects of nine plant-derived compounds utilizing EPC cells and largemouth bass. Among them, quercetin demonstrated a notable inhibitory effect on LMBRaV replication in EPC, with a reduction of 93.6% at 20 mg/L. Quercetin exerts its anti-LMBRaV properties on cells may result from its ability to inhibit viral entry, mitigate nuclear damage, and inactivate the virus directly. In vivo experiments showed that the preventive protection rate of quercetin against LMBRaV infection in largemouth bass reached 57.7%, and decreased LMBRaV viral loads in liver, spleen and kidney. Moreover, quercetin appeared to induce the expression of several immune-related genes, including interferon (IFN), and major histocompatibility complex 1 (MHC-1), myxovirus resistance 1 (MX1), and nuclear factor erythroid 2-related factor 2 (Nrf2), suggesting its potential for immunoregulation. Furthermore, quercetin mitigated the pathological alterations in the immune organs of largemouth bass infected with LMBRaV. In summary, quercetin shows promise as an immunomodulatory agent against LMBRaV infections in largemouth bass.

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