Comparative genomics of Tn6411 transposons carrying the blaIMP-1 gene in Pseudomonas aeruginosa

文献类型： 外文期刊

第一作者： Zheng, Lin

作者： Zheng, Lin;Wang, Zixian;Lu, Gejin;Jing, Jie;Sun, Shiwen;Sun, Yang;Ji, Xue;Jiang, Bowen;Zhu, Lingwei;Guo, Xuejun;Guo, Jingyi;Guan, Jiayao;Wang, Yongjie;Zhao, Chuanfang

作者机构：

期刊名称：PLOS ONE （ 影响因子：2.9； 五年影响因子：3.3 ）

ISSN： 1932-6203

年卷期： 2024 年 19 卷 7 期

页码：

收录情况： SCI

摘要： We aimed to determine the molecular characteristics of carbapenem-resistant Pseudomonas aeruginosa strains 18081308 and 18083286, which were isolated from the urine and the sputum of two Chinese patients, respectively. Additionally, we conducted a comparative analysis between Tn6411 carrying bla(IMP-1) in strain 18083286 and transposons from the same family available in GenBank. Bacterial genome sequencing was carried out on strains 18081308 and 18083286 to obtain their whole genome sequence. Average nucleotide identity (ANI) was used for their precise species identification. Serotyping and multilocus sequence typing were performed. Furthermore, the acquired drug resistance genes of these strains were identified. The carbapenem-resistant P. aeruginosa strains isolated in the present study were of sequence type ST865 and serotype O6. They all carried the same resistance genes (aacC2, tmrB, and bla(IMP-1)). Tn6411, a Tn7-like transposon carrying bla(IMP-1), was found in strain 18083286 by single molecule real time (SMRT) sequencing. We also identified the presence of this transposon sequence in other chromosomes of P. aeruginosa and plasmids carried by Acinetobacter spp. in GenBank, indicating the necessity for heightening attention to the potential transferability of this transposon.

分类号：

  • 相关文献
作者其他论文 更多>>

微信小程序