Chemical composition and in vitro intestinal probiotic properties analysis of exopolysaccharides from screened Streptococcus thermophilus 90301

文献类型： 外文期刊

第一作者： Wang, Xiaochan

作者： Wang, Xiaochan;Mahsa, Ghahvechi Chaeipeima;Rui, Xin;Li, Wei;Lin, Tao;Lin, Yihan;Xu, Chang;Ma, Kai;Zhang, Changliang;Ji, Feng;Ma, Kai;Zhang, Changliang;Ji, Feng

作者机构：

关键词： Extracellular polysaccharides; Structural analysis; Gastrointestinal digestion; Probiotics

期刊名称：INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES （ 影响因子：8.5； 五年影响因子：8.7 ）

ISSN： 0141-8130

年卷期： 2025 年 311 卷

页码：

收录情况： SCI

摘要： A strain of Streptococcus thermophilus 90301, characterized by robust growth and high exopolysaccharide (EPS) production, was selected. Following isolation and purification, two EPS components, EPS-1 and EPS-2, were obtained. The analysis revealed that EPS-1 was composed of mannose, rhamnose, glucosamine, glucose, and galactose with molar ratios of 0.94:0.09:0.11:1.00:0.16, whereas EPS-2 was composed of mannose, ribose, glucose, and galactose with molar ratios of 15.11:0.26:1.00:0.38; respectively. The average molecular weights were determined to be 2.31 x 105 Da for EPS-1 and 2.41 x 105 Da for EPS-2. Furthermore, the prebiotic potential of the two fractions (EPS-1 and EPS-2) was investigated through in vitro simulation of human fecal fermentation digestion. Both EPS-1 and EPS-2 were not digested by the digestive fluids and were able to significantly modulate the composition of the gut microbiota. Additionally, they enhanced the gut microbiota's ability to produce short-chain fatty acids. These findings provide some basis for the functional application of polysaccharide components extracted from S. thermophilus 90301 as a potential prebiotic.

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