Hypoglycemic mechanism of foxtail millet prolamin hydrolysate in type 2 diabetic mice revealed by metabolomics and 16S rRNA sequencing

文献类型： 外文期刊

第一作者： Zhu, Yiqing

作者： Zhu, Yiqing;Wu, Tong;Zhao, Qingyu;Yue, Li;Zhao, Liangxing;Zhi, Li;Wu, Xiaomeng;Xue, Yong;Shen, Qun;Fu, Yongxia;Yue, Li

作者机构：

关键词： Foxtail millet prolamin hydrolysate; Type 2 diabetes; Gut microbiota; Serum metabolomics

期刊名称：FOOD BIOSCIENCE （ 影响因子：5.9； 五年影响因子：6.1 ）

ISSN： 2212-4292

年卷期： 2025 年 66 卷

页码：

收录情况： SCI

摘要： Foxtail millet prolamin hydrolysate (FMPH) has demonstrated hypoglycemic effects, though its underlying mechanisms remain unclear. This study used 16S rRNA sequencing and serum metabolomics to investigate the effects of FMPH on blood glucose metabolism in type 2 diabetes (T2D) mice (male, C57BL/6J). The results showed that FMPH supplementation improved weight loss, hyperglycemia, hyperlipidemia, insulin resistance, serum hormone levels, and inflammatory markers while mitigating liver, kidney, and pancreatic damage in T2D mice. FMPH shifted gut microbiota composition, increasing the abundance of Firmicutes and Actinomycetota while reducing Bacteroidota, which was associated with elevated concentrations of short-chain fatty acids, particularly acetic and propionic acids. Furthermore, FMPH normalized serum metabolites related to glycerophospholipid and tryptophan metabolism. Key metabolites, including PC(18:0/0:0) and PE(20:0/20:3 (5Z,8Z,11Z)), were closely associated with specific bacteria (Ileibacterium and Bifidobacterium) and T2D indicators. These findings recommend that the hypoglycemic effects of FMPH may be mediated through gut microbiota alteration and metabolic regulation, highlighting its potential as a functional food for the prevention and management of T2D.

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