6-Shogaol Mitigates Sepsis-Associated Hepatic Injury through Transcriptional Regulation

文献类型： 外文期刊

第一作者： Guo, Xiaoxuan

作者： Guo, Xiaoxuan;Qiu, Jing;Qian, Yongzhong

作者机构：

关键词： 6-shogaol; LPS; liver injury; RNA sequencing; MAPK pathway; NF kappa B pathway

期刊名称：NUTRIENTS （ 影响因子：5.719； 五年影响因子：6.352 ）

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年卷期： 2021 年 13 卷 10 期

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收录情况： SCI

摘要： Sepsis-associated liver dysfunction presents a significant public health problem. 6-Shogaol is the key bioactive component in dry ginger, which has antioxidant and anti-inflammation capacity. The present study aims to investigate the preventive effect of 6-shogaol on sepsis-induced liver injury. 6-Shogaol was administered to mice for 7 consecutive days before being intraperitoneally injected with lipopolysaccharide (LPS). After 24 h, mice were sacrificed, and biochemical and transcriptomic analyses were performed. Our results demonstrated that 6-shogaol prevented LPS-induced impairment in antioxidant enzymes and elevation in malondialdehyde level in the liver. The hepatic inflammatory response was significantly suppressed by 6-shogaol through suppressing the MAPK/NF kappa B pathway. RNA-sequencing data analysis revealed that 41 overlapped genes between the LPS vs. control group and 6-shogaol vs. LPS group were identified, among which 36 genes were upregulated, and 5 genes were downregulated for the LPS vs. control group. These overlapped genes are enriched in inflammation-related pathways, e.g., TNF and NF kappa B. The mRNA expression of the overlapped genes was also verified in the LPS-induced BRL-3A cell model. In summary, 6-shogaol shows great potential as a natural chemopreventive agent to treat sepsis-associated hepatic disorders.

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