Spirodiclofen Analogues as Potential Lipid Biosynthesis Inhibitors: A Convenient Synthesis, Biological Evaluation, and Structure-Activity Relationship
文献类型: 外文期刊
第一作者: Ke, Shaoyong
作者: Ke, Shaoyong;Sun, Tingting;Zhang, Zhigang;Zhang, Ya-Ni;Liang, Ying;Wang, Kaimei;Yang, Ziwen
作者机构:
关键词: Spirodiclofen analogues;Synthesis;Biological activity;Structure-activity relationship
期刊名称:BULLETIN OF THE KOREAN CHEMICAL SOCIETY ( 影响因子:0.969; 五年影响因子:0.691 )
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收录情况: SCI
摘要: Twenty spirodiclofen analogues have been designed and conveniently synthesized via three steps including esterifi-cation, one-pot heterocyclization, and acylation reactions. The target molecules have been identified on the basis of analytical spectra (~1H NMR, ~(13)C NMR and ESI-MS) data. All newly synthesized compounds have been screened for their potential insecticidal and herbicidal activity by standard method. The preliminary assays indicated that some of analogues displayed moderate to good insecticidal activity against Plutella xylostella compared with spirodiclofen, and some compounds showed obvious activity against Brassica chinensis. Structure-activity relationship (SAR) is also discussed based on the experimental data.
分类号: O6
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