文献类型： 外文期刊
第一作者： Zhou, Zhu-Gui
作者： Zhou, Zhu-Gui;Chen, Xi;Li, Dong-Dong;Chen, Ying;Man, Ruo-Jun
作者机构：
关键词： Flavonoids; Structural modification; Drug design; Anti-tumor activity; Mechanisms; Apoptosis
期刊名称：CURRENT TOPICS IN MEDICINAL CHEMISTRY （ 影响因子：3.57； 五年影响因子：4.255 ）
ISSN： 1568-0266
年卷期： 2022 年 22 卷 7 期
页码：
收录情况： SCI
摘要： Flavonoids are secondary metabolites of plants. In general,most flavonoids are combined with glucosides and have extremely complex molecular structures. In nature, these flavonoids have a variety of biological activities, such as anti-oxidation,anti-virus, anti-tumor, scavenging free radicals, etc.; however,due to poor solubility and stability of flavonoids,their bioavailability is limited. The drug design method is used to modify the structure of flavonoids to give them special properties. At present, flavonoids have shown broad application prospects in treating tumors, inhibiting proliferation, migration, invasion, angiogenesis, and multi-drug resistance of tumors and have become a research hotspot.
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