文献类型： 外文期刊
第一作者： Jia WanZhong
作者： Jia WanZhong;Li, Zhi;Lun ZhaoRong;Jia WanZhong;Li, Zhi;Lun ZhaoRong;Jia WanZhong
作者机构：
关键词： immune surveillance;viral genomic distribution;MicroRNA functions;viral genomic discovery
期刊名称：CHINESE SCIENCE BULLETIN （ 影响因子：1.649； 五年影响因子：1.738 ）
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年卷期：
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收录情况： SCI
摘要： Virus-encoded microRNAs (miRNAs) are a new kind of miRNAs that regulate the expression of target gene in host cells or viruses through inducing cleavage of mRNA, repressing translation, etc., and change the processes of host cells or replicate viruses to escape or resist immune surveillance of host and protect viruses themselves. It has become a hot topic to discover viral genes encoding miRNAs and their target genes, and to identify their functions. This review provides background information on the history of virally encoded miRNAs including their genomic distribution, functions and mechanisms. In addition, we discuss the similarities and differences between virus- and host-encoded miRNAs, the future directions of researches in viral miRNAs and their applications in diseases control and therapy.
分类号： N1
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