The LRR receptor-like kinase ALR1 is a plant aluminum ion sensor

文献类型： 外文期刊

第一作者： Ding, Zhong Jie

作者： Ding, Zhong Jie;Xu, Chen;Wang, Yu Xuan;Cui, Meng Qi;Yuan, Jun Jie;Wang, Ya Nan;Wu, Yun Rong;Xu, Ji Ming;Li, Chun Xiao;Mao, Chuan Zao;Harberd, Nicholas P.;Zheng, Shao Jian;Xu, Chen;Zheng, Shao Jian;Yan, Jing Ying;Li, Gui Xin;Wu, Jian Xiang;Shi, Yuan Zhi;Guo, Jiang Tao;Zhou, Jian Min;Zhou, Jian Min;Benhamed, Moussa;Harberd, Nicholas P.;Zheng, Shao Jian

作者机构：

期刊名称：CELL RESEARCH （ 影响因子：44.1； 五年影响因子：39.3 ）

ISSN： 1001-0602

年卷期： 2024 年 34 卷 4 期

页码：

收录情况： SCI

摘要： Plant survival requires an ability to adapt to differing concentrations of nutrient and toxic soil ions, yet ion sensors and associated signaling pathways are mostly unknown. Aluminum (Al) ions are highly phytotoxic, and cause severe crop yield loss and forest decline on acidic soils which represent similar to 30% of land areas worldwide. Here we found an Arabidopsis mutant hypersensitive to Al. The gene encoding a leucine-rich-repeat receptor-like kinase, was named Al Resistance1 (ALR1). Al ions binding to ALR1 cytoplasmic domain recruits BAK1 co-receptor kinase and promotes ALR1-dependent phosphorylation of the NADPH oxidase RbohD, thereby enhancing reactive oxygen species (ROS) generation. ROS in turn oxidatively modify the RAE1 F-box protein to inhibit RAE1-dependent proteolysis of the central regulator STOP1, thus activating organic acid anion secretion to detoxify Al. These findings establish ALR1 as an Al ion receptor that confers resistance through an integrated Al-triggered signaling pathway, providing novel insights into ion-sensing mechanisms in living organisms, and enabling future molecular breeding of acid-soil-tolerant crops and trees, with huge potential for enhancing both global food security and forest restoration.

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