Metavirome of 31 tick species provides a compendium of 1,801 RNA virus genomes

文献类型： 外文期刊

第一作者： Ni, Xue-Bing

作者： Ni, Xue-Bing;Cui, Xiao-Ming;Jiang, Jia-Fu;Sun, Yi;Wang, Qian;Zhao, Lin;Ma, Ke;Shen, Shi-Jing;Zhang, Ming-Zhu;Guo, Wen-Bin;Li, Liang-Jing;Zhu, Dai-Yun;Zhang, Jie;Xia, Luo-Yuan;Du, Li-Feng;Shi, Wen-Qiang;Pan, Yu-Sheng;Zhou, Yu-Hao;Jia, Na;Cao, Wu-Chun;Ni, Xue-Bing;Wu, Yu-Qian;Shum, Marcus Ho-Hin;Oong, Xiang-Yong;Lam, Tommy Tsan-Yuk;Ni, Xue-Bing;Wu, Yu-Qian;Shum, Marcus Ho-Hin;Oong, Xiang-Yong;Lam, Tommy Tsan-Yuk;Ni, Xue-Bing;Wu, Yu-Qian;Shum, Marcus Ho-Hin;Lam, Tommy Tsan-Yuk;Jia, Na;Cao, Wu-Chun;Cui, Xiao-Ming;Jiang, Jia-Fu;Jia, Na;Cao, Wu-Chun;Liu, Jin-Yue;Ye, Run-Ze;Zhao, Lin;Xia, Luo-Yuan;Du, Li-Feng;Cao, Wu-Chun;Chang, Qiao-Cheng;Han, Xiao-Hu;Zhu, Jin-Guo;Zhan, Lin;Ding, Shu-Jun;Ruan, Xiang-Dong;Shao, Hong-Ze;Que, Teng-Cheng;Liu, Guang-Yuan;Du, Chun-Hong;Huang, En-Jiong;Wang, Xin;Wang, Chong-Cai;Qu, Jiang-Li;Ma, Jiang;Gong, Cai-Wei;Chen, Qi-Qing;Qin, Qian;Lam, Tommy Tsan-Yuk;Lam, Tommy Tsan-Yuk;Lam, Tommy Tsan-Yuk;Jia, Na

作者机构：

期刊名称：NATURE MICROBIOLOGY （ 影响因子：28.3； 五年影响因子：22.9 ）

ISSN： 2058-5276

年卷期： 2023 年 8 卷 1 期

页码：

收录情况： SCI

摘要： The increasing prevalence and expanding distribution of tick-borne viruses globally have raised health concerns, but the full repertoire of the tick virome has not been assessed. We sequenced the meta-transcriptomes of 31 different tick species in the Ixodidae and Argasidae families from across mainland China, and identified 724 RNA viruses with distinctive virome compositions among genera. A total of 1,801 assembled and complete or nearly complete viral genomes revealed an extensive diversity of genome architectures of tick-associated viruses, highlighting ticks as a reservoir of RNA viruses. We examined the phylogenies of different virus families to investigate virome evolution and found that the most diverse tick-associated viruses are positive-strand RNA virus families that demonstrate more ancient divergence than other arboviruses. Tick-specific viruses are often associated with only a few tick species, whereas virus clades that can infect vertebrates are found in a wider range of tick species. We hypothesize that tick viruses can exhibit both 'specialist' and 'generalist' evolutionary trends. We hope that our virome dataset will enable much-needed research on vertebrate-pathogenic tick-associated viruses.

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